JOURNAL ARTICLE
REVIEW

Pramipexole: in restless legs syndrome

Paul L McCormack, M Asif A Siddiqui
CNS Drugs 2007, 21 (5): 429-37; discussion 438-40
17447832
Pramipexole is an oral, non-ergoline dopamine agonist with selectivity for the dopamine D(3) receptor, which was recently approved in the EU and the US for the treatment of idiopathic restless legs syndrome (RLS) in adults. In a polysomnographic study, pramipexole 0.125, 0.25, 0.50 or 0.75 mg once daily for 3 weeks significantly reduced from baseline the periodic limb movement index compared with placebo (-27 to -53 vs -3). Pramipexole at a median dosage of 0.35 mg/day for 6 weeks significantly reduced from baseline the mean International RLS Study Group rating scale (IRLS) score compared with placebo (-12.4 vs -6.1) and produced a significantly higher response ('much improved' or 'very much improved') rate (63% vs 33%) according to the Clinical Global Impressions-Improvement (CGI-I) scale. In a controlled-withdrawal study in which responders to pramipexole following 6 months' therapy were randomised to pramipexole or placebo for 12 weeks, significantly less pramipexole than placebo recipients reached the target event of predefined worsening of symptoms (21% vs 86%). Treatment with pramipexole 0.25, 0.50 or 0.75 mg once daily for 12 weeks significantly reduced IRLS scores from baseline values (-13 to -14 vs -9) and produced significantly higher proportions of CGI-I responders (68-75% vs 51%) compared with placebo. Pramipexole was generally well tolerated, with most adverse events being transient and of mild to moderate severity.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
17447832
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"