Freewheel exercise training modifies pro- and anti-apoptotic protein expression in mouse splenic lymphocytes

L Hoffman-Goetz, P A Spagnuolo
International Journal of Sports Medicine 2007, 28 (9): 787-91
The purpose of this study was to examine the effect of voluntary training in mice on the expression of apoptotic proteins in splenic lymphocytes following acute exercise. Thirty-three mice were randomized to four treatments: 1) control group (no training and no acute exercise), 2) training, no acute exercise, 3) no training, acute exercise and 4) training, acute exercise. Mice were sacrificed immediately after acute exercise. Western immunoblotting was used to detect apoptosis in splenic lymphocytes for concentrations of anti- (Bcl-2) and pro-apoptotic (caspase 3) proteins. Plasma corticosterone was used as an index of exercise stress. Trained mice not given acute exercise challenge had elevated Bcl-2 (p < 0.05) and lower caspase 3 (p < 0.05) levels relative to control mice. Following the acute exercise challenge, however, trained and untrained mice did not differ in the concentrations of these proteins in splenocytes. Thus, freewheel exercise training in mice reduces splenic lymphocyte apoptosis when tissue samples are obtained at rest but not after acute exercise.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"