JOURNAL ARTICLE

Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa

Sang Un Choi, Nam-In Baek, Sung-Hoon Kim, Jae Heon Yang, Jae Soon Eun, Tae Yong Shin, Jong Pil Lim, Jae Hyeok Lee, Hoon Jeon, Mi-Young Yun, Kang-Hyun Leem, Hee Wook Park, Dae Keun Kim
Archives of Pharmacal Research 2007, 30 (2): 151-4
17366734
Three known isoquinoline alkaloids were isolated from the chloroform-soluble fraction of the methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) through repeated column chromatography. Their chemical structures were elucidated as corynoline (1), corynoloxine (2) and 6-oxocorynoline (3) using spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2 and HCT15 tumor cells.

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