JOURNAL ARTICLE

Spiral-wave dynamics depend sensitively on inhomogeneities in mathematical models of ventricular tissue

T K Shajahan, Sitabhra Sinha, Rahul Pandit
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 2007, 75 (1): 011929
17358206
Every sixth death in industrialized countries occurs because of cardiac arrhythmias such as ventricular tachycardia (VT) and ventricular fibrillation (VF). There is growing consensus that VT is associated with an unbroken spiral wave of electrical activation on cardiac tissue but VF with broken waves, spiral turbulence, spatiotemporal chaos and rapid, irregular activation. Thus spiral-wave activity in cardiac tissue has been studied extensively. Nevertheless, many aspects of such spiral dynamics remain elusive because of the intrinsically high-dimensional nature of the cardiac-dynamical system. In particular, the role of tissue heterogeneities in the stability of cardiac spiral waves is still being investigated. Experiments with conduction inhomogeneities in cardiac tissue yield a variety of results: some suggest that conduction inhomogeneities can eliminate VF partially or completely, leading to VT or quiescence, but others show that VF is unaffected by obstacles. We propose theoretically that this variety of results is a natural manifestation of a complex, fractal-like boundary that must separate the basins of the attractors associated, respectively, with spiral breakup and single spiral wave. We substantiate this with extensive numerical studies of Panfilov and Luo-Rudy I models, where we show that the suppression of spiral breakup depends sensitively on the position, size, and nature of the inhomogeneity.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
17358206
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"