JOURNAL ARTICLE

Diagnosis and treatment of interval sentinel lymph nodes in patients with cutaneous melanoma

Tobias Carling, Deborah Pan, Stephan Ariyan, Deepak Narayan, Carolyn Truini
Plastic and Reconstructive Surgery 2007, 119 (3): 907-13
17312495

BACKGROUND: Interval sentinel lymph nodes in patients with melanoma are occasionally found outside conventional nodal basins. In this study, the authors examined the frequency, location, and incidence of nodal metastasis of such interval nodes in a large cohort of patients with primary cutaneous melanoma.

METHODS: Between September of 1997 and February of 2003, 374 consecutive patients at the Yale Cancer Center Melanoma Unit underwent sentinel lymph node biopsy for primary cutaneous melanoma with a Breslow thickness of at least 1.0 mm and/or Clark IV or greater histologic dermal invasion. All patients underwent preoperative lymphoscintigraphy to map the lymphatic drainage for the primary lesion and intraoperative confirmation, and biopsy was performed on all sentinel lymph nodes identified.

RESULTS: Unequivocal interval sentinel lymph nodes were identified in eight of 374 patients (2.1 percent). Three of these eight patients had metastatic spread to the interval sentinel nodes. In four of the eight patients, the interval sentinel lymph node was not located in the anticipated lymphatic pathway between the primary tumor and the sentinel lymph node basin.

CONCLUSIONS: Interval sentinel nodes seem as likely to contain micrometastatic disease as those in the expected sentinel lymph node basin. Half of the subjects displayed interval sentinel lymph nodes that were not in the anticipated lymphatic pathway between the primary tumor and the sentinel lymph node basin. These findings suggest that adequate preoperative lymphoscintigraphy and intraoperative recognition of interval nodes are of paramount importance in the treatment of melanoma.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
17312495
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.