JOURNAL ARTICLE
REVIEW

Polymorphisms associated with coronary heart disease: better by the score

Dov Shiffman, Charles M Rowland, John J Sninsky, James J Devlin
Current Opinion in Molecular Therapeutics 2006, 8 (6): 493-9
17243484
Coronary heart disease (CHD) has a genetic component independent of traditional risk factors. However, the risk associated with individual genetic polymorphisms is likely modest, and therefore initial claims of associations with CHD require testing in other studies. We surveyed the literature for studies that retested polymorphisms previously reported to be associated with CHD, and found that these associations were reproduced for only 15 of the 172 polymorphisms considered. This review discusses how the modest risk associated with each individual polymorphism generates false-positive, as well as false-negative results. Common strategies to address these issues are described, including methods to aggregate risk estimates from several polymorphisms into a genetic risk score.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
17243484
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.