The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review

Kenji Morimoto, Shou Lin, Kathleen Sakamoto
Molecular Genetics and Metabolism 2007, 90 (4): 358-62
The relatively new study of ribosomal proteins has allowed for greater understanding of protein synthesis; however the connection between ribosomal proteins' roles and that of disease pathophysiology has not yet been established. RPS19 is a ribosomal protein linked to Diamond-Blackfan anemia whose functions have begun to be elucidated. We review here the known roles of RPS19 in both ribosome construction and other extra-ribosomal functions and discuss their relationship to Diamond-Blackfan anemia.

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