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In vino veritas: a tale of two sirt1s?

Seung-Hoi Koo, Marc Montminy
Cell 2006 December 16
Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.

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