[Effects of NO-synthase inhibitors on maturation mouse oocytes in cumulus-oocyte complexes]

T Iu Voznesenskaia, T V Blashkiv
Ontogenez 2006, 37 (6): 465-8
We studied the effects of various NO-synthase inhibitors on meioitic maturation of mouse oocytes in vitro in cumulus-oocyte complexes isolated from follicles of varying sizes. Selective and nonselective inhibitors of NO-synthase isoforms suppressed meiotic maturation of oocytes to varying degrees, which was expressed in a decreased number of oocytes at metaphase II. The results obtained suggest that the role of inducible form of NO-synthase (iNOS) increases with the development of follicles and oocytes.

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