The mesangium as a target for glomerulopathic light and heavy chains: pathogenic considerations in light and heavy chain-mediated glomerular damage

John Keeling, Guillermo A Herrera
Contributions to Nephrology 2007, 153: 116-34
Certain structurally abnormal light and heavy chains are known to be nephrotoxic and alter mesangial homeostasis producing pathological alterations. Many of the mechanisms involved in light chain-mesangial interactions have been deciphered using an in vitro model, providing a framework for understanding the sequence of events that leads to irreversible glomerular changes and eventually renal failure. The molecular events involved in the pathogenesis of these disorders are now for the most part well-established. These studies have delineated the sequence of steps involved and crucial events have been determined. An animal model is being developed which will undoubtedly contribute significantly to validate the information that has been obtained from the in vitro models. The present chapter will address the pathogenesis of these disorders with an emphasis on highlighting crucial steps possibly amenable to therapeutic intervention to stop or ameliorate adverse consequences leading to irreversible changes.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.