Pain related potentials by electrical stimulation of skin for detection of small-fiber neuropathy in HIV

Zaza Katsarava, Ozgüt Yaldizli, Christina Voulkoudis, Hans-Christoph Diener, Helger Kaube, Matthias Maschke
Journal of Neurology 2006, 253 (12): 1581-4
We compared the sensitivity of pain related evoked potentials (PREP), a novel electrophysiological technique, with standard nerve conduction (SNC) testing in the diagnosis of small fiber neuropathy in 47 patients with HIV infection and 31 age matched controls. SNC testing revealed a neuropathy in only 31%, whereas PREP was abnormal in 74% of symptomatic patients. This result hints that PREP is more sensitive in the detection of HIV-associated small fiber neuropathy than standard neurography.


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