JOURNAL ARTICLE

Molecular epidemiology of dengue type 3 virus in Brazil and Paraguay, 2002-2004

Victor H Aquino, Elen Anatriello, Paula F Gonçalves, Eliana V DA Silva, Pedro F C Vasconcelos, Deusylene S Vieira, Weber C Batista, Maria L Bobadilla, Cynthia Vazquez, Mirian Moran, Luiz T M Figueiredo
American Journal of Tropical Medicine and Hygiene 2006, 75 (4): 710-5
17038699
We studied the molecular epidemiology of dengue virus type 3 (DENV-3) in Brazil and Paraguay by analyzing the 5' and 3' untranslated regions (5' and 3'UTRs) and the E protein gene of viruses isolated between 2002 and 2004. Both 5' and 3'UTRs were highly conserved. However, the 3'UTR of two isolates from Brazil contained eight nucleotide deletions compared with the remaining 26 viruses. Phylogenetic analyses suggested that DENV-3 was introduced into Brazil from the Caribbean Islands at least twice and into Paraguay from Brazil at least three times.

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