JOURNAL ARTICLE

[The relativity of vascular endothelium growth factor receptor-1 and preeclampsia]

Cui-lan Zou, Xing-hui Liu, Ben-ming Yue, Jia-hong Fu, Guo-lin He
Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition 2006, 37 (5): 765-8
17037747

OBJECTIVES: (1) To investigate the levels of the serum soluble endothelial growth factor receptor-1 in women with preeclampsia and compare the difference between the groups of the mild preeclampsia, severe preeclampsia and eclampsia. For more, to analyze the relativity between the levels of the serum soluble vascular growth factor receptor-1 and preeclampsia. (2) To detect the expression of the membrane-bound VEGFR-1 protein in the placenta tissue of the women with preeclampsia and compare the difference between the groups of the mild preeclampsia, severe preeclampsia and eclampsia, Then to analyze the relativity between the expression of the membrane-bound endothelial growth factor receptor-1 and preeclampsia.

METHODS: (1) The serum levels of sVEGFR-1 in 10 women with mild preeclampsia, 10 women with severe preeclampsia, 10 women with eclampsia, 10 women without preeclampsia were detected by the quantitative sandwich enzyme immunoassay technique. (2) Immunohistochemistry and quantitative analysis were used to detect membrane-bound VEGFR-1 contents and distribution in the placenta tissue.

RESULTS: (1) The results showed that the serum sVEGFR-1 levels of all preeclampsia groups were relatively higher than those of control group (P < 0.05) and that there were significant differences between the groups of the mild preeclampsia, severe preeclampsia and eclampsia. (2) In placentas, the positive staining was detected predominantly in the membranes of villus syncytiotrophoblast cells, extravillous trophoblast cells, and villus endothelial cells. In fetal membranes, the positive staining was detected predominantly in amnionic endothelial cells. (3) The contents of membrane-bound VEGFR-1 in placenta of preeclampsia groups were relatively lower than that of control group. There were significant differences between membrane-bound VEGFR-1 contents of the mild preeclampsia,severe preeclampsia and eclampsia (P < 0.05). (4) The ratio of the sVEGFR-1 concentration in serum and the membrane-bound VEGFR-1 contents in placenta of preeclampsia groups (sVEGFR-1/ membrane-bound VEGFR-1) was relatively higher than that of control group (P < 0.05) and there were significant differences between the groups of the mild preeclampsia, severe preeclampsia and eclampsia (P < 0.05).

CONCLUSIONS: (1) The serum sVEGFR-1 levels of preeclampsia groups were relatively higher than those of control group, the VEGFR-1 may be related to preeclampsia. (2) The contents of membrane-bound VEGFR-1 in placenta of preeclampsia groups were relatively lower than that of control group, the membrane-bound VEGFR-1 may relate to preeclampsia. (3) The ratio of the sVEGFR-1 concentration in serum and the membrane-bound VEGFR-1 contents in placenta of preeclampsia groups (sVEGFR-1/membrane-bound VEGFR-1) was relatively higher than that of control group, the preeclampsia may contribute to VEGFR-1/ PLGF and sVEGFR-1/membrane-bound.

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