Acute systemic immune activation following conjunctival exposure to staphylococcal enterotoxin B

Govindarajan Rajagopalan, Michele K Smart, Robin Patel, Chella S David
Infection and Immunity 2006, 74 (10): 6016-9
Conjunctival exposure to the Staphylococcus aureus superantigen staphylococcal enterotoxin B (SEB) may occur accidentally, as a result of bioterrorism, or during colonization or infection of the external eye. Using human leukocyte antigen class II transgenic mice, we show for the first time that conjunctival exposure to SEB can cause robust systemic immune activation.

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