Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon.

Wassim Y Almawi, Saria F Wakim-Ghorayeb, Mona R Arekat, Pierre Najm, Sose H Keleshian, Nasreen Al-Sayed, Bruno Blanchon, Hanady R Samaha, Noha Irani-Hakime

Clinical and Vaccine Immunology : CVI 2006 November

The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.

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