Leukopheresis therapy for severe infantile pertussis with myocardial and pulmonary failure

Marek J Grzeszczak, Kevin B Churchwell, Kathryn M Edwards, John Pietsch
Pediatric Critical Care Medicine 2006, 7 (6): 580-2

OBJECTIVE: To describe an infant with severe pertussis successfully treated with leukopheresis.

DESIGN: Case report.

SETTING: Pediatric intensive care unit of a children's hospital.

PATIENT: Five-wk-old female with pertussis complicated by cardiorespiratory failure.

INTERVENTIONS: Single leukopheresis treatment.

MEASUREMENTS AND MAIN RESULTS: Normalization of the white blood cell count and marked cardiorespiratory improvement after treatment; patient survived.

CONCLUSION: Given the temporal association between treatment and improvement, we hypothesize that the markedly elevated white blood cell count has a major role in the cardiopulmonary compromise.

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