Association of transient tachypnea of the newborn and childhood asthma

David J Birnkrant, Charlene Picone, Wendy Markowitz, Mohammed El Khwad, Wen Hsin Shen, Nebiat Tafari
Pediatric Pulmonology 2006, 41 (10): 978-84

OBJECTIVE: To determine if transient tachypnea of the newborn (TTN) is independently associated with childhood asthma.

METHODS: The sampling frame was a computerized database on 18,379 term infants born between January 1, 1996 and December 31, 2000 in an urban tertiary care hospital. This was a case-control study nested in a cohort of all term newborns who were subsequently diagnosed with asthma (n = 2137) and a similar number of birthday-matched controls. The International Classification of Diseases, Ninth Revision code was used to identify the infants with TTN and those who developed asthma. Logistic regression was used to adjust for potentially confounding variables. Stratified multivariate analysis was undertaken on subgroups to assess possible effect modification by factors known to influence the incidence of asthma: race, gender, domicile, and maternal asthma.

RESULTS: After adjustment for potential confounding, TTN was significantly associated with the diagnosis of childhood asthma (adjusted OR = 1.50, 95% CI: 1.13-1.99; P = 0.0052). The association of TTN and asthma was statistically strongest among male infants, especially among males whose mothers lived at an urban address, males of non-white race, and males whose mothers did not have asthma. The pattern of association of TTN and asthma was similar for infants diagnosed with asthma once compared with those diagnosed with asthma recurrently.

CONCLUSION: TTN was independently and significantly associated with the subsequent diagnosis of childhood asthma, especially among male infants. TTN may be a marker of deficient pulmonary function reflecting inherited susceptibility to asthma.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.