An influenza A/H3 outbreak during the 2004/2005 winter in elderly vaccinated people living in a nursing home

A M Iorio, M Neri, E Lepri, B Camilloni, M Basileo, N Sigismondi, C Fabiani, L Calzoletti, S Puzelli, I Donatelli
Vaccine 2006 November 10, 24 (44): 6615-9
This study examined the antibody response against the three vaccine antigens and the epidemic A/H3N2 drift variant (A/California) and the prevention of laboratory diagnosed influenza infections in a group of elderly institutionalized people vaccinated with the 2004/2005 influenza vaccine. Antibody titres were measured by hemagglutination inhibition (HI) in sera collected before and 1 month after vaccination. Laboratory diagnosis was done examining throat swabs (RT-PCR or MDCK cell culture) or by serology (seroconversion comparing HI titres in sera collected 1 and 5 months after vaccination). Results obtained showed that influenza vaccination induced an adequate immune response against the three vaccine antigens and the epidemic A/H3N2 variant, however it was not capable of preventing an influenza outbreak due to the new A/H3N2 (A/California) variant.

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