JOURNAL ARTICLE

[Psychotropic effects of diazepam in male mice with alternative psycho-emotional statuses]

A V Amikishieva, S N Semendiaeva
Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova 2006, 92 (4): 488-98
16813155
Effects of diazepam (0.1, 0.5 and 1 microg/kg, i. p.) on communicative, anxious behaviors, exploratory activities and sexual motivation of C57BL/6J male mice with alternative psychoemotional statuses (intact and anxious) were studied. Increased level on anxiety was formed by sensory contacts technique. Behavioral effects of diazepam depend on initial psycho-emotional status of animals. The compound has an anxiolytic effect in new situation on anxious males but does not have it in situation of social contacts. Diazepam reinforces initial sexual interest in anxious mice; however, it does not enable correct exhaustion of sexual motivation. Furthermore, the compound provokes development of the exhaustion in intact male mice.

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