We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Microalbuminuria in the intensive care unit: Clinical correlates and association with outcomes in 431 patients.
Critical Care Medicine 2006 August
OBJECTIVE: Comparison of urine albumin within 6 hrs of intensive care unit (ICU) admission with demography, clinical classification, outcome, inotrope/vasopressor requirement, clinical assessment of mortality risk, and Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores.
DESIGN: Urine albumin-creatinine ratio (ACR) was measured on ICU admission (ACR 1) and after 4-6 hrs (ACR 2).
SETTING: A 17-bed general ICU in a university teaching hospital.
PATIENTS: Unselected medical (206) and surgical (225) patients recruited prospectively.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: Bedside urine ACR was measured by nurses using a Bayer DCA 2000 analyzer and expressed in mg/mmol (reference range <2.3). ACR 1 in medical and surgical patients was 15.5 (12.4-19.5) and 8.2 (5.9-11.1) mg/mmol, respectively (p = .0002), and ACR 2 was 9.0 (5.8-12.5) and 4.6 (3.6-5.3), respectively (p < .0001). For all patients, median (95% confidence interval) ACR fell from 11.2 (8.7-13.2) to 5.4 (4.7-6.8) mg/mmol 4-6 hrs after ICU admission (p < .0001). ACR 1 for nonsurvivors (n = 90) and survivors (n = 341) was 16.1 (11.2-21.3) and 8.8 (6.9-11.9), respectively (p = .0002) and ACR 2, 12.4 (8.2-18.9) and 4.8 (3.9-5.4), respectively (p < .0001). In both medical and surgical patients who died on the ICU, median ACR failed to decrease significantly following admission. ACR1 and ACR 2 were higher in patients who required inotropic or vasopressor support and correlated with duration of therapy. ACR 1 and 2 were inversely correlated with mean Po2/Fio2 ratio 48 hrs after ICU admission and positively correlated with duration of mechanical ventilation and ACR 1 with ICU stay. ACR 2 predicted mortality and ACR 1 inotrope requirement independent of clinical mortality risk assessment and APACHE II and SOFA scores.
CONCLUSIONS: Urine albumin changes rapidly within the first 6 hrs following ICU admission and predicts ICU mortality and inotrope requirement as well as or better than APACHE II and SOFA scores. Serial urine albumin measurement may provide a means of monitoring the microvascular effects of systemic inflammation.
DESIGN: Urine albumin-creatinine ratio (ACR) was measured on ICU admission (ACR 1) and after 4-6 hrs (ACR 2).
SETTING: A 17-bed general ICU in a university teaching hospital.
PATIENTS: Unselected medical (206) and surgical (225) patients recruited prospectively.
INTERVENTIONS: None.
MEASUREMENTS AND MAIN RESULTS: Bedside urine ACR was measured by nurses using a Bayer DCA 2000 analyzer and expressed in mg/mmol (reference range <2.3). ACR 1 in medical and surgical patients was 15.5 (12.4-19.5) and 8.2 (5.9-11.1) mg/mmol, respectively (p = .0002), and ACR 2 was 9.0 (5.8-12.5) and 4.6 (3.6-5.3), respectively (p < .0001). For all patients, median (95% confidence interval) ACR fell from 11.2 (8.7-13.2) to 5.4 (4.7-6.8) mg/mmol 4-6 hrs after ICU admission (p < .0001). ACR 1 for nonsurvivors (n = 90) and survivors (n = 341) was 16.1 (11.2-21.3) and 8.8 (6.9-11.9), respectively (p = .0002) and ACR 2, 12.4 (8.2-18.9) and 4.8 (3.9-5.4), respectively (p < .0001). In both medical and surgical patients who died on the ICU, median ACR failed to decrease significantly following admission. ACR1 and ACR 2 were higher in patients who required inotropic or vasopressor support and correlated with duration of therapy. ACR 1 and 2 were inversely correlated with mean Po2/Fio2 ratio 48 hrs after ICU admission and positively correlated with duration of mechanical ventilation and ACR 1 with ICU stay. ACR 2 predicted mortality and ACR 1 inotrope requirement independent of clinical mortality risk assessment and APACHE II and SOFA scores.
CONCLUSIONS: Urine albumin changes rapidly within the first 6 hrs following ICU admission and predicts ICU mortality and inotrope requirement as well as or better than APACHE II and SOFA scores. Serial urine albumin measurement may provide a means of monitoring the microvascular effects of systemic inflammation.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app