JOURNAL ARTICLE

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies

Keng-Chang Tsai, Shih-Yuan Chen, Po-Huang Liang, I-Lin Lu, Neeraj Mahindroo, Hsing-Pang Hsieh, Yu-Sheng Chao, Lincoln Liu, Donald Liu, Wei Lien, Thy-Hou Lin, Su-Ying Wu
Journal of Medicinal Chemistry 2006 June 15, 49 (12): 3485-95
16759091
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3C-like protease (3CL(pro) or M(pro)) is an attractive target for the development of anti-SARS drugs because of its crucial role in the viral life cycle. In this study, a compound database was screened by the structure-based virtual screening approach to identify initial hits as inhibitors of SARS-CoV 3CL(pro). Out of the 59,363 compounds docked, 93 were selected for the inhibition assay, and 21 showed inhibition against SARS-CoV 3CL(pro) (IC(50) <or= 30 microM), with three of them having common substructures. Furthermore, a search for analogues with common substructure in the Maybridge, ChemBridge, and SPECS_SC databases led to the identification of another 25 compounds that exhibited inhibition against SARS-CoV 3CL(pro) (IC(50) = 3-1,000 microM). These compounds, 28 in total, were subjected to 3D-QSAR studies to elucidate the pharmacophore of SARS-CoV 3CL(pro).

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