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JOURNAL ARTICLE

Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

Sheng-Jun Dai, Meng Chen, Ke Liu, Yong-Tao Jiang, Li Shen
Chemical & Pharmaceutical Bulletin 2006, 54 (6): 869-72
16755060
Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.9-7.8 muM.

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