Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine

James A Bourgeois, Faraz Farzin, James A Brunberg, Flora Tassone, Paul Hagerman, Lin Zhang, David Hessl, Randi Hagerman
Journal of Neuropsychiatry and Clinical Neurosciences 2006, 18 (2): 171-7
The authors present a case of a patient with dementia with mood symptoms and multiple neurological manifestations of fragile X-associated tremor/ataxia syndrome (FXTAS). Despite a gradually deteriorating neurological course, he was managed for 2 years with combination therapy of donepezil and venlafaxine, which resulted in improvement and relative stabilization of his psychiatric status. Psychiatrists are hereby alerted to the description of a novel dementia syndrome that may respond to pharmacological intervention commonly used for other dementias.

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