Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy

R Lodi, G Pierangeli, C Tonon, S Cevoli, C Testa, G Bivona, F Magnifico, P Cortelli, P Montagna, B Barbiroli
Neurology 2006 April 25, 66 (8): 1264-6
The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

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