We have located links that may give you full text access.
JOURNAL ARTICLE
REVIEW
Vasopressin antagonism: potential impact on neurologic disease.
Clinical Neuropharmacology 2006 March
Hyponatremia is a common electrolyte disorder frequently associated with central nervous system (CNS) diseases, neurosurgical procedures, and the use of neurotropic drugs. The clinical manifestations of hyponatremia are attributable to an increase in brain water content that occurs in response to a decrease in serum osmolality. Hyponatremia triggers adaptive processes in the brain to limit this cerebral swelling, but a rapid fall in serum [Na(+)] may overwhelm this adaptive mechanism. Patients with hyponatremia for more than 48 hours are at risk for developing osmotic demyelination when overly rapid correction of hyponatremia restores serum osmolality before this adaptive process can be reversed. The infusion of hypertonic saline for the restoration of serum [Na(+)] should therefore be carefully controlled to avoid this potentially devastating complication. Other options currently available for the treatment of hyponatremia, including strict restriction of fluid intake, are limited by their inconsistent response, poor tolerability, and frequent adverse effects. Arginine vasopressin (AVP)-receptor antagonists promote aquaresis (electrolyte-sparing excretion of free water) by blocking the antidiuretic action of the hormone at the level of the collecting ducts. In clinical trials, AVP-receptor antagonists increased serum [Na] in patients with euvolemic or hypervolemic hyponatremia associated with various conditions, including syndrome of inappropriate antidiuretic hormone secretion (SIADH). Patients who have neurologic disease with SIADH-related hyponatremia may be good candidates for treatment with AVP-receptor antagonists. Careful assessment of intravascular volume status before initiation of therapy and strict monitoring of the serum [Na] during treatment are necessary to avoid complications.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app