JOURNAL ARTICLE
REVIEW

Non-invasive antenatal RHD typing

C E Van der Schoot, A Ait Soussan, J Koelewijn, G Bonsel, L G C Paget-Christiaens, M de Haas
Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine 2006, 13 (1-2): 53-7
16564727
The existence of cell free fetal DNA, derived from apoptotic syncytiotrophoblast, in the maternal circulation has opened new possibilities of non-invasive prenatal diagnosis. Although still some technical problems exists, especially the lack of a generic positive control on the presence of fetal DNA and the aspecific amplification of background maternal DNA, non-invasive prenatal RHD typing has been successfully introduced in several laboratories, especially in Europe. The diagnostic accuracy reaches>99%. In the Netherlands PCR guided administration of antenatal anti-D prophylaxis is cost-effective and nearby. In this review the main characteristics and applications of cell free fetal DNA are discussed, with an emphasis on prenatal RHD genotyping.

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