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Prepubertal depression: diagnostic and therapeutic dilemmas.

Childhood depression is underrecognized. Longitudinal studies have found that depression is a chronic and relapsing disorder in children aged 6 years and older. Now there is evidence that a depressive syndrome can occur in preschool children. Defining depressive syndromes in preschool and elementary-school children has been a challenge. Children should be seen in the context of their social environment (ie, family and peer group) and their larger physical and cultural surroundings. A developmental perspective is important in diagnosing psychopathology in children. Evaluation should include a complete medical assessment to rule out underlying medical causes. A structured clinical interview and rating scales are helpful in determining whether a child or adolescent is depressed. Evidence-based treatment guidelines are limited. The diagnosis of depression in young children remains an active area of debate and study. Clearly more research is needed.

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Group 7SearchHeart failure treatmentPapersTopicsCollectionsEffects of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Patients With Heart Failure Importance: Only 1 class of glucose-lowering agents-sodium-glucose cotransporter 2 (SGLT2) inhibitors-has been reported to decrease the risk of cardiovascular events primarily by reducingSeptember 1, 2017: JAMA CardiologyAssociations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study.CONCLUSIONS: Increased UACR is common in patients with heart failure, including non-diabetics. Urinary albumin creatininineJul, 2011: European Journal of Heart FailureRandomized Controlled TrialEffects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.Review

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