JOURNAL ARTICLE

[Expression and clinical significance of apoptosis-related oncogenes in stage I-II non-small cell lung cancer]

Dao-Feng Wang, Can-Guang Zeng, Yong-Bin Lin, Jing-Hui Hou, Zhi-Hua Zhu
Ai Zheng, Aizheng, Chinese Journal of Cancer 2006, 25 (3): 359-62
16536995

BACKGROUND & OBJECTIVE: The prognosis of stage I-II non-small cell lung cancer (NSCLC) after operation is related to many factors. Apoptosis-related oncogenes play an important role in occurrence and development of tumors. This study was to investigate the expression and prognostic significance of representative apoptosis-related oncogenes (Survivin, Bcl-2, Bax, and Fas) in stage I-II NSCLC.

METHODS: The expression of Survivin, Bcl-2, Bax, and Fas in 115 specimens of stage I-II NSCLC and 20 specimens of non-tumor lung tissue were detected by SP immunohistochemistry.

RESULTS: The positive rates of Survivin and Bcl-2 were significantly higher in NSCLC than in non-tumor lung tissues (62.61% vs. 10.00%, P<0.001; 49.57% vs. 15.00%, P<0.05); the positive rates of Bax and Fas were significantly lower in NSCLC than in non-tumor lung tissues (31.30% vs. 65.00%, P<0.05; 46.96% vs. 80.00%, P<0.05). TNM stage and positive expression of Survivin were independent prognostic factors of stage I-II NSCLC (P<0.01). The survival time of patients was significantly shorter in Survivin-positive group than in Survivin-negative group [(33+/-7) months vs. (52+/-9) months, P<0.05].

CONCLUSIONS: Apoptosis-related oncogenes may have some impacts on the occurrence and development of stage I-II NSCLC. TNM stage and positive expression of Survivin are independent prognostic factors.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
16536995
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"