Guaiane sesquiterpenoids from Torilis japonica and their cytotoxic effects on human cancer cell lines

Hye Won Park, Sang-Un Choi, Nam-In Baek, Sung-Hoon Kim, Jae Soon Eun, Jae Heon Yang, Dae Keun Kim
Archives of Pharmacal Research 2006, 29 (2): 131-4
A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1beta-hydroxy-4-guaien-3-one (1beta-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-1alpha-hydroxy-4-guaien-3-one (1alpha-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.

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