COMMENT
JOURNAL ARTICLE

Rejuvenating exhausted T cells during chronic viral infection

Taku Okazaki, Tasuku Honjo
Cell 2006 February 10, 124 (3): 459-61
16469690
In a recent paper in Nature, show that the immunoreceptor PD-1 is upregulated by "exhausted" T cells during the chronic phase of viral infection in mice. Remarkably, blocking the interaction between PD-1 and its ligand, PD-L1, reactivates these T cells and reduces viral load.

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