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Research Support, Non-U.S. Gov't
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Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients.

Jean Michel Petit, David Masson, Anne Minello, Laurence Duvillard, Francoise Galland, Bruno Verges, Philippe Gambert, Patrick Hillon
Molecular Genetics and Metabolism 2006 June
OBJECTIVES: It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis.

METHODS: Eighty-six chronic hepatitis C patients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/T MTP polymorphism on steatosis.

RESULTS: Steatosis was observed in 39 patients (45.3%). The 493G/T MTP polymorphism were not related to the development of steatosis.

CONCLUSION: The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.

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