COMPARATIVE STUDY
JOURNAL ARTICLE

Comparative efficacy of ethanol and isopropanol against feline calicivirus, a norovirus surrogate

Yashpal S Malik, Sunil Maherchandani, Sagar M Goyal
American Journal of Infection Control 2006, 34 (1): 31-5
16443090

BACKGROUND: Improper disinfection of environmental surfaces contaminated by the feces or vomitus of infected patients is believed to be a major cause of the spread of noroviruses (NoV) in close institutional settings. Although several disinfectants are available, the search for safe and effective disinfectant continues. Because alcohol and alcohol-based products have been used as antiseptics and their efficacy against several enveloped viruses has been documented, we wanted to determine their efficacy against nonenveloped calicivirus.

METHODS: Feline calicivirus (FCV) was used as a surrogate for NoVs, using the carrier test. We evaluated the virucidal efficacy of various concentrations of ethanol and isopropanol against FCV, dried on an inanimate, nonporous contact surface for contact times of 1, 3, and 10 minutes. The virus was eluted after alcohol treatment and titrated in feline kidney cells. Percentage virus inactivation was calculated by comparing these titers with those obtained with virus eluted from controls.

RESULTS: Ethanol at 70% and 90% and isopropanol at 40% to 60% concentrations were found to be the most effective, killing 99% of FCV within a short contact time of 1 minute.

CONCLUSION: Isopropanol was more efficacious than ethanol at 40% to 60% concentrations, suggesting that the use of an appropriate concentration of isopropanol or ethanol would help in controlling the transmission of NoVs from environmental contact surfaces.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
16443090
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"