JOURNAL ARTICLE

Prediction of cardiovascular morbidity and mortality: comparison of the internal carotid artery resistive index with the common carotid artery intima-media thickness

Daniel Staub, Alessandro Meyerhans, Beat Bundi, Hans Peter Schmid, Beat Frauchiger
Stroke; a Journal of Cerebral Circulation 2006, 37 (3): 800-5
16439703

BACKGROUND AND PURPOSE: The intima-media thickness (IMT) of the common carotid artery (CCA) is well correlated with the degree of arteriosclerosis and is a predictor of cardiovascular morbidity and mortality. The (hemodynamic) resistive index (RI) of the internal carotid artery (ICA) correlates with the degree of arteriosclerosis just as well as IMT. The aim of the study was to compare the predictive values of RI and IMT with regard to cardiovascular morbidity and mortality.

METHODS: A total of 146 patients with cardiovascular risk factors or established arteriosclerosis were included. Duplex sonography of the CCA and ICA was performed, and the IMT and RI were measured in both vessels. During follow-up for a median of 36 months, the occurrence of cardiovascular events (myocardial infarction, stroke, or cardiovascular death) was assessed.

RESULTS: Thirty-nine cardiovascular events occurred in 28 patients (19.2%). The relative risk for a cardiovascular event per increase of the IMT by 1 SD (0.16 mm) was 1.53 (95% CI, 1.07 to 2.18) and 1.91 (95% CI, 1.34 to 2.73) for RI ICA (0.08). The event rate in patients with IMT <0.79 mm (mean) and RI ICA <0.66 (mean) was 11.8% and 12.7% compared with 25.6% (P=0.03) and 25.0% (P=0.06) in patients with IMT > or =0.79 mm and RI ICA > or =0.66, respectively. Log rank analysis showed a continuous increase in the risk of cardiovascular event with increasing range of the IMT (P=0.029) and RI ICA (P<0.001).

CONCLUSIONS: The RI ICA is a predictor of cardiovascular mortality and morbidity, at least comparable to the well-established IMT.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
16439703
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"