JOURNAL ARTICLE

Persistent B-cell lymphopenia, multiorgan disease, and erythema multiforme caused by Mycoplasma pneumoniae infection

Baldassarre Martire, Caterina Foti, Nicoletta Cassano, Rosalba Buquicchio, Giovanni Carlo Del Vecchio, Domenico De Mattia
Pediatric Dermatology 2005, 22 (6): 558-60
16354262
We report a 6-year-old girl in whom Mycoplasma pneumoniae infection presenting with erythema multiforme, multiorgan, and hematologic dysfunctions induced a long-standing, marked B-cell lymphopenia. An increase of CD8+ lymphocytes was also detected. We suggest that a selective cytotoxic T lymphocyte-dependent B cell lysis and the expansion of super-antigen activated CD8+ T cells may account for the multiorgan and hematologic disturbances triggered by M. pneumoniae.

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