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Syntheses, in vitro antibacterial and antifungal activities of a series of N-alkyl, 1,4-dithiines.
Il Farmaco 2005 November
A series of dithiines were synthesized by cyclization of 4-(alkylamino)-4-oxobutanoic acids under the action of SOCl2. Their in vitro antibacterial and antifungal activities have been evaluated against reference strains and versus reference compounds. The so-called 'isoimides' 2a, 2b were totally inactive whereas some imides had low MICs for few bacteria and for few fungal microorganisms.
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