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JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
SYSTEMATIC REVIEW
Treatment approaches to symptoms associated with frontotemporal degeneration.
Current Psychiatry Reports 2005 October
A systematic review of the literature reveals few randomized, controlled trials for drug therapy in frontotemporal degeneration (FTD). Although there is evidence to support a serotonergic deficit, and clinicians frequently prescribe selective serotonin reuptake inhibitors to patients with FTD, only paroxetine and trazodone have been studied. There is Class II evidence for use of rivastigmine in FTD behavioral disturbances, although there is no consistent evidence of cholinergic deficit in this illness.
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