Immunogenicity and safety of two live-attenuated tetravalent dengue vaccine formulations in healthy Australian adults

Scott Kitchener, Michael Nissen, Peter Nasveld, Remi Forrat, Sutee Yoksan, Jean Lang, Jean-François Saluzzo
Vaccine 2006 February 27, 24 (9): 1238-41
We conducted a Phase 1b study to evaluate the immunogenicity and safety of two live attenuated tetravalent dengue vaccines in healthy adult volunteers. After one injection, all subjects reported systemic reactions consistent with a mild dengue-like syndrome. Seven volunteers developed dengue 3 viraemia after vaccination. All subjects developed a neutralizing antibody response against serotype 3 with partial response against other serotypes. The trial was stopped early (after 10 subjects enrolled) due to formulation issues, which were related to the dengue 3 vaccine component. Managing viral interference and balancing attenuation to produce acceptable tetravalent immunogenicity with minimal reactogenicity may be a recurring problem for future multivalent live vaccines.

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