We have located links that may give you full text access.
ENGLISH ABSTRACT
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
[Effect of protective ventilation and open lung strategy on extravascular lung water in rabbits with acute respiratory distress syndrome].
Chinese Journal of Tuberculosis and Respiratory Diseases 2005 September
OBJECTIVE: To study the effect of protective ventilation and open lung strategy on extravascular lung water index (EVLWI) in rabbits with acute respiratory distress syndrome (ARDS).
METHODS: Saline-lavaged, anesthetized ARDS rabbits were divided into (1) a moderate tidal volume (V(T)) zero positive end-expiratory pressure (PEEP) group (MVZP group): V(T) 12 ml/kg, PEEP 0 cm H2O; (2) a low V(T) zero PEEP group (LVZP group): V(T) 6 ml/kg, PEEP 0 cm H2O; (3) a low V(T) best PEEP group (LVBP group): V(T) 6 ml/kg, PEEP 10 cm H2O; (4) a low V(T) best PEEP + sustained inflation (SI) group (LVBP + SI group): V(T) 6 ml/kg, PEEP 10 cm H2O + SI. EVLWI was measured by single indicator thermodilution technique at baseline, 0, 1, 2 and 3 h.
RESULTS: In the MVZP, LVZP, LVBP, and LVBP + SI groups, EVLWI in the ARDS model [(22.3 +/- 5.6), (20.0 +/- 3.8), (25.7 +/- 9.7), (22.5 +/- 6.2) ml/kg, respectively] was significantly higher than those at baseline [(11.3 +/- 2.4), (10.2 +/- 2.4), (10.3 +/- 4.6), (9.7 +/- 2.3) ml/kg, respectively, all P < 0.05]. In the MVZP group, EVLWI at 2 h and 3 h [(32.0 +/- 12.2), (36.2 +/- 12.4) ml/kg] was higher than that of 0 h [(22.3 +/- 5.6) ml/kg, P < 0.05]. In the LVZP group EVLWI at 2 h and 3 h [(27.8 +/- 12.9), (30.3 +/- 13.0) ml/kg] was also higher than that of 0 h [(20.0 +/- 3.8) ml/kg, P < 0.05]. In the LVBP group, EVLWI at 1 h was (18.5 +/- 8.1) ml/kg and was lower than that of 0 h [(25.7 +/- 9.7) ml/kg, P = 0.027]. In the LVBP + SI group, EVLWI at 1, 2, 3 h [(16.8 +/- 6.5), (18.0 +/- 7.1), (15.7 +/- 2.7) ml/kg] was lower than that of 0 h [(22.5 +/- 6.2) ml/kg, all P < 0.05]. There was significant difference among the four groups at 1 h and 3 h (all P < 0.05). At 1 h and 3 h, compared with MVZP group, EVLWI of the LVBP and the LVBP + SI groups were significantly decreased (all P < 0.05). At 3 h, compared with the EVLWI of the LVZP group, EVLWI of the LVBP + SI group was significantly decreased (P < 0.05).
CONCLUSION: Lung protective ventilation and open lung strategy could decrease EVLWI.
METHODS: Saline-lavaged, anesthetized ARDS rabbits were divided into (1) a moderate tidal volume (V(T)) zero positive end-expiratory pressure (PEEP) group (MVZP group): V(T) 12 ml/kg, PEEP 0 cm H2O; (2) a low V(T) zero PEEP group (LVZP group): V(T) 6 ml/kg, PEEP 0 cm H2O; (3) a low V(T) best PEEP group (LVBP group): V(T) 6 ml/kg, PEEP 10 cm H2O; (4) a low V(T) best PEEP + sustained inflation (SI) group (LVBP + SI group): V(T) 6 ml/kg, PEEP 10 cm H2O + SI. EVLWI was measured by single indicator thermodilution technique at baseline, 0, 1, 2 and 3 h.
RESULTS: In the MVZP, LVZP, LVBP, and LVBP + SI groups, EVLWI in the ARDS model [(22.3 +/- 5.6), (20.0 +/- 3.8), (25.7 +/- 9.7), (22.5 +/- 6.2) ml/kg, respectively] was significantly higher than those at baseline [(11.3 +/- 2.4), (10.2 +/- 2.4), (10.3 +/- 4.6), (9.7 +/- 2.3) ml/kg, respectively, all P < 0.05]. In the MVZP group, EVLWI at 2 h and 3 h [(32.0 +/- 12.2), (36.2 +/- 12.4) ml/kg] was higher than that of 0 h [(22.3 +/- 5.6) ml/kg, P < 0.05]. In the LVZP group EVLWI at 2 h and 3 h [(27.8 +/- 12.9), (30.3 +/- 13.0) ml/kg] was also higher than that of 0 h [(20.0 +/- 3.8) ml/kg, P < 0.05]. In the LVBP group, EVLWI at 1 h was (18.5 +/- 8.1) ml/kg and was lower than that of 0 h [(25.7 +/- 9.7) ml/kg, P = 0.027]. In the LVBP + SI group, EVLWI at 1, 2, 3 h [(16.8 +/- 6.5), (18.0 +/- 7.1), (15.7 +/- 2.7) ml/kg] was lower than that of 0 h [(22.5 +/- 6.2) ml/kg, all P < 0.05]. There was significant difference among the four groups at 1 h and 3 h (all P < 0.05). At 1 h and 3 h, compared with MVZP group, EVLWI of the LVBP and the LVBP + SI groups were significantly decreased (all P < 0.05). At 3 h, compared with the EVLWI of the LVZP group, EVLWI of the LVBP + SI group was significantly decreased (P < 0.05).
CONCLUSION: Lung protective ventilation and open lung strategy could decrease EVLWI.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices 
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app