[Proton magnetic resonance spectroscopy in the liver of HIV and HCV coinfected patients].

UNLABELLED: The 1H MR spectroscopy (1H MRS) creates possibility of non-invasive study of morphological changes 1H MRS and metabolic disturbance of the liver. The aim of study was estimated of 1H MRS in investigation of liver metabolic changes, with special regard of lipids in patients with HCV and HIV/HCV infection.

MATERIAL AND METHODS: Research was moved among patients with HCV infection and in HCV/ HIV co infection. 1H MRS of the liver was moved with use of system Picker, Eclipse 1.5 T. Investigation were executed with use of tube of whole body, with use of sequence PRESS 35 (TE 35 ms, TR 1500 ms, nex 192). Suppression of water was made of MOIST method. Voxel about sizes 3x3x3 (27 cm3) were located in right piece of liver on basis of paintings T2- dependence in front and transverse planes.

RESULT: In group of HCV patients without HIV infection were observed over 6 x increase proportion of PME/TL (0.112; p = 0.001) and 2 x increase of Glx/TL (0.042; p = 0.02) in refer to control group. In patients with HCV and HIV infection were observed significance increase of Glu/ TL - 328%, Glx/TL - 458% and PME/TL 728% in comparison to control group. The patients with only HCV infection were statistical significance decrease of TL level in comparison to control group (43.2 +/- 9.4 v. 74.1 +/- 12.2; p = 0.09). The patients with HCV and HIV infection, level of TL was lowered in refer patients with only HCV infection (20.7 +/- 5.6; p < 0.05).

CONCLUSIONS: Proton magnetic resonance spectroscopy of the liver is useful diagnostic method in detecting of parenchyma liver damage and to make up supplement of histology diagnosis.