RESEARCH SUPPORT, NON-U.S. GOV'T
[Study of the clinicopathology on verruciform xanthoma of the oral cavity].
PURPOSE: Three cases of oral cavity mucosal verruciform xanthoma were studied to investigate the pathogenesis of verruciform xanthoma.
METHODS: Immunohistochemical staining with S-P and in situ hybridization using the probe to detect HPV mRNA and MMP-2, MMP-9 RNA.
RESULTS: The foam cells were strongly positive for CD68 (KP1) and Vimentin. The cytokeratin, PCNA and S-100 showed negative in foam cells. ISH testing failed to detect HPV (types 6, 11, 16, 18) in any of the three cases of verruciform xanthoma. MMP-2, MMP-9 showed positive staining in epithelial cells and foam cells.
CONCLUSIONS: Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells like that, are most likely derived from monocyte-macrophage lineage.
METHODS: Immunohistochemical staining with S-P and in situ hybridization using the probe to detect HPV mRNA and MMP-2, MMP-9 RNA.
RESULTS: The foam cells were strongly positive for CD68 (KP1) and Vimentin. The cytokeratin, PCNA and S-100 showed negative in foam cells. ISH testing failed to detect HPV (types 6, 11, 16, 18) in any of the three cases of verruciform xanthoma. MMP-2, MMP-9 showed positive staining in epithelial cells and foam cells.
CONCLUSIONS: Verruciform xanthoma is most likely not a human papillomavirus associated lesion and the foam cells like that, are most likely derived from monocyte-macrophage lineage.
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