Dengue 2 genotypes in the state of Oaxaca, Mexico

A Cisneros, A Díaz-Badillo, G Cruz-Martínez, R Tovar, L R Ramírez-Palacios, F Jiménez-Rojas, B Beaty, W C Black, M de Lourdes Muñoz
Archives of Virology 2006, 151 (1): 113-25
To genetically characterize dengue 2 (DEN-2) viruses in Oaxaca, Mexico, the C protein, and a portion of the prM protein genes of 8 isolates from the 2001 DEN epidemic were sequenced. The sequences were compared to those of prototype DEN-2 viruses from various parts of the world. Phylogenetic analysis suggested that the 2001 isolates of DEN-2 were of the American/Asian genotype and were most similar to the Jamaica and Venezuelan isolates MARA3, LARD1996 and LARD1910. Molecular analyses confirmed the origin of the isolates. This study indicates that DEN-2 strains of American/Asian genotype probably from Southeast Asian are circulating in Oaxaca.

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