Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma

Mei-Jou Chen, Jehn-Hsiahn Yang, Tusi-Lien Mao, Hong-Nerng Ho, Yu-Shih Yang
Fertility and Sterility 2005, 84 (1): 217

OBJECTIVE: To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor.

DESIGN: Case report.

SETTING: Infertility center in university hospital.

PATIENT(S): An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor.

INTERVENTION(S): Chromosomal analysis, bilateral gonadectomy, donor oocyte, and IVF program.

MAIN OUTCOME MEASURE(S): Tumor markers and pregnancy result.

RESULT(S): The patient was free from tumor recurrence after 13 years' follow-up. A successful twin pregnancy was achieved after oocyte donation and IVF.

CONCLUSION(S): Gonadectomy without adjuvant therapies could be done in 46,XY gonadal dysgenetic women with gonadoblastoma in view of preservation of future fertility.

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