Whole-body PET/CT: spectrum of physiological variants, artifacts and interpretative pitfalls in cancer patients

Luis Gorospe, Subha Raman, Jon Echeveste, Norbert Avril, Yolanda Herrero, Susana Herna Ndez
Nuclear Medicine Communications 2005, 26 (8): 671-87
Accurate diagnosis and staging in oncology is essential in the evaluation of cancer for optimal patient outcome. Conventional imaging techniques, such as computed tomography (CT), rely basically on morphological changes for tumour detection. Clinical experience, however, shows that morphological criteria may be misleading and may not always allow differentiation between benign and malignant lesions. Positron emission tomography (PET) with [F]fluorodeoxyglucose (FDG) is rapidly gaining a critical role in the clinical evaluation of patients with cancer. However, PET lacks anatomical landmarks for topographic orientation, and identification of abnormal glucose metabolic activity in regions close to organs with variable physiological FDG uptake can be difficult. To overcome these difficulties, a combined PET/CT scanner that acquires both functional (PET) and CT images has been recently developed. Proper interpretation of PET (and PET/CT) images requires a thorough understanding of the normal physiological distribution of FDG in the body, along with a knowledge of frequently encountered physiological variations in FDG distribution, and recognition of non-malignant causes of FDG uptake that can be confused with a malignant neoplasm. In addition, because of the utilization of the CT transmission information for the correction of the attenuation of the PET emission data (and for the reconstruction of the PET images), some artifacts may be generated. As a consequence, CT based attenuation correction of PET images may result in erroneous PET/CT interpretations. The aim of this extensively illustrated paper is to demonstrate several potential pitfalls encountered during the interpretation of PET/CT images so that radiologists can avoid false positive diagnoses and recognize inherently non-specific findings on PET/CT images obtained for oncological diagnosis.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"