Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002

J Anthony G Scott, Salim Mwarumba, Caroline Ngetsa, Salome Njenga, Brett S Lowe, Mary P E Slack, James A Berkley, Isaiah Mwangi, Kathryn Maitland, Mike English, Kevin Marsh
Antimicrobial Agents and Chemotherapy 2005, 49 (7): 3021-4
Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.

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