Factors predictive of LASIK flap thickness with the Hansatome zero compression microkeratome.

PURPOSE: To determine the explanatory power of preoperative variables and comeal flap thickness in laser in situ keratomileusis (LASIK) using the Hansatome zero compression microkeratome (Bausch & Lomb, Rochester, NY).

METHODS: A prospective, nonrandomized, comparative interventional case study was performed on 250 eyes of 129 consecutive patients who underwent LASIK surgery using the Hansatome zero compression microkeratome. A 160-microm or 180-microm microkeratome head and an 8.5- or 9.5-mm suction ring were used in the procedures. Preoperative measurements included refraction, spherical equivalent, keratometry, intraocular pressure, corneal white-to-white, anterior chamber depth, and corneal eccentricity. Corneal thickness was measured intraoperatively using ultrasonic pachymetry before and after flap creation, and the difference was taken as flap thickness. Flap diameter was measured with a corneal gauge. Data were analyzed using simple, multiple, stepwise linear and non-linear regression analyses and two-tailed t tests.

RESULTS: The mean flap thickness was 124 +/- 17 microm with the nominal 160-microm head and 142 +/- 20 microm with the nominal 180-microm head. One third (33%) of the total variation in flap thickness could be accounted for by three preoperative variables: average corneal thickness, spherical equivalent refraction, and choice of 160- or 180-microm microkeratome head. A simple correlation of 0.114 was noted between corneal eccentricity and flap thickness, but this variable did not add significant explanatory power on multiple regression analysis. Linear regression analysis allowed determination of a flap thickness nomogram with a standard error of the estimate of 16.9 microm and a 95% confidence interval of +/- 33.1.

CONCLUSIONS: Comeal thickness is the most systematic predictor of corneal flap thickness using the Hansatome microkeratome. Because three preoperative variables account for only 33% of the range in flap thickness, future studies should focus on variations in blade extension and corneal biomechanical factors, which may also play an important role in determining flap thickness.