Kikuchi-Fujimoto disease is a rare cause of lymphadenopathy and fever of unknown origin in children: report of two cases and review of the literature

Paola Scagni, Maria Grazia Peisino, Maurizio Bianchi, Maura Morello, Nicola Sardi, Alessandra Linari, Luana Mastrodicasa, Enrico Madon, Paola Pecco
Journal of Pediatric Hematology/oncology 2005, 27 (6): 337-40
Kikuchi-Fujimoto disease, a benign and unusual self-limiting histiocytic necrotizing lymphadenitis of unknown origin, should be included in the differential diagnosis of lymphadenopathy and fever of unknown origin. This disease mostly affects young Asian women and has rarely been reported in children, thus remaining a poorly recognized entity that is frequently confused with malignant lymphoma. The authors describe two children with Kikuchi-Fujimoto disease, with particular attention to diagnostic approach and clinical and histologic features of the disease.

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