The alphabeta versus gammadelta T cell fate decision: when less is more

Ellen Robey

Immunity 2005, 22 (5): 533-4

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TCR signal strength influences alphabeta/gammadelta lineage fate. Sandra M Hayes, Liqi Li, Paul E Love Immunity 2005, 22 (5): 583-93

Integrated morphogen signal inputs in gammadelta versus alphabeta T-cell differentiation. Heather Melichar, Joonsoo Kang Immunological Reviews 2007, 215: 32-45

Strength of signal: a fundamental mechanism for cell fate specification. Sandra M Hayes, Paul E Love Immunological Reviews 2006, 209: 170-5

Recent insights into the signals that control alphabeta/gammadelta-lineage fate. Jens Peter H Lauritsen, Mariëlle C Haks, Juliette M Lefebvre, Dietmar J Kappes, David L Wiest Immunological Reviews 2006, 209: 176-90

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage. Mariëlle C Haks, Juliette M Lefebvre, Jens Peter H Lauritsen, Michael Carleton, Michele Rhodes, Toru Miyazaki, Dietmar J Kappes, David L Wiest Immunity 2005, 22 (5): 595-606

Development and selection of gammadelta T cells. Na Xiong, David H Raulet Immunological Reviews 2007, 215: 15-31

Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Heather J Melichar, Kavitha Narayan, Sandy D Der, Yoshiki Hiraoka, Noemie Gardiol, Gregoire Jeannet, Werner Held, Cynthia A Chambers, Joonsoo Kang Science 2007 January 12, 315 (5809): 230-3

Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. E E Eynon, F Livák, K Kuida, D G Schatz, R A Flavell Journal of Immunology 1999 February 1, 162 (3): 1448-59

An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells. Inge Van de Walle, Greet De Smet, Magda De Smedt, Bart Vandekerckhove, Georges Leclercq, Jean Plum, Tom Taghon Blood 2009 March 26, 113 (13): 2988-98

gammadelta and alphabeta T cell lineage choice: resolution by a stronger sense of being. Gladys W Wong, Juan Carlos Zúñiga-Pflücker Seminars in Immunology 2010, 22 (4): 228-36

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