Hypoglycaemic activity of Retama raetam in rats

Mhamed Maghrani, Jean-Baptiste Michel, Mohamed Eddouks
Phytotherapy Research: PTR 2005, 19 (2): 125-8
The purpose of this study was to determine the underlying mechanism of the hypoglycaemic activity of an aqueous extract perfusion of Retama raetam (RR) in normal and streptozotocin-induced diabetic rats. The aqueous extract was administered intravenously and the blood glucose changes were determined within 4 h after starting the treatment. Plasma insulin concentrations and glycosuria were determined. The aqueous RR extract at a dose of 10 mg[sol ]kg[sol ]h produced a significant decrease in blood glucose levels in normal rats (p < 0.001) and an even more marked decrease in diabetic rats (p < 0.001). This hypoglycaemic effect might be due to an extra-pancreatic action of the aqueous extract of RR, since the basal plasma insulin concentrations were unchanged after RR treatment. A potent increase of glycosuria was observed both in normal and diabetic rats (p < 0.001). It is concluded that an aqueous extract perfusion of RR caused a potent inhibition of renal glucose reabsorption. This renal effect is at least one mechanism to explain the observed hypoglycaemic activity of this plant in normal and diabetic rats.

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