We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Maternal and umbilical venous levels of endothelin in women with pre-eclampsia.
Journal of Human Hypertension 1992 Februrary
Endothelin is a recently discovered, potent vasoconstrictive peptide. To investigate its involvement in pre-eclampsia, we measured its concentration in the plasma of 10 healthy non-pregnant women, 19 healthy pregnant women in early pregnancy, 26 healthy pregnant women in the third trimester, 18 women with pre-eclampsia in the third trimester and 6 women with pre-eclampsia in the postpartum period. In addition, the concentration of endothelin in umbilical venous plasma was measured in 7 healthy pregnant women and in 4 with pre-eclampsia. A sandwich-enzyme immunoassay for endothelin-1[1-21] was used. The plasma concentration of endothelin in pre-eclampsia significantly exceeded that of the healthy pregnant women during the third trimester. In pre-eclampsia this elevated level of plasma endothelin normalised with the fall in blood pressure 7 days postpartum. The level of endothelin in the umbilical vein was 6 to 8 times higher than that in the cubital vein both in the healthy pregnant women and in those with pre-eclampsia, but there was no significant difference in the umbilical venous plasma concentration of endothelin between those two groups. These observations suggest that the synthesis of endothelin may be increased in pre-eclampsia and that this increase may play a role in the elevation of peripheral vascular resistance and the production of peripheral ischaemic damage. Damage to the endothelial cells may then stimulate the synthesis of endothelin to initiate a vicious cycle.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app