In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002

Samuel K Bouchillon, Daryl J Hoban, Brian M Johnson, Tim M Stevens, Michael J Dowzicky, David H Wu, Patricia A Bradford
Diagnostic Microbiology and Infectious Disease 2005, 51 (4): 291-5
Tigecycline is the first glycylcycline antimicrobial in phase III clinical trials. This study compares the in vitro activity of tigecycline to 12 other predominately broad-spectrum antimicrobials against 3049 recent inpatient isolates from 38 clinical centers in 17 countries. The minimum concentration at which tigecycline inhibited 90% of the isolates for the entire collection, excluding Pseudomonas aeruginosa, was 1 microg/mL, including vancomycin-resistant enterococci-, extended-spectrum beta-lactamase-, and methicillin-resistant Staphylococcus aureus-resistant phenotypes.

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